Excessive intake of high fructose, high risk of bowel cancer 2019-07-15

Excessive intake of high fructose, high risk of bowel cancer

Drinking a bottle of sugary drink daily may promote the growth of large intestines.
According to a new study published in the US Science on the 22nd, the experiment was to feed a certain amount of high-fructose corn syrup into mice (equivalent to about 340 ml of soda per day for adults), which will directly promote the growth of large intestines. This experimental data is the latest evidence that sugar intake may promote the growth of cancerous tumors. Although the study is not sufficient to directly prove that human intake of high fructose corn syrup will lead to colorectal cancer growth, the conclusions of the study may be used to treat and prevent colorectal cancer.
The main research author, Marcus Goncalves, an endocrinologist at Cornell University's Weill School of Medicine, recommends that high-risk groups of large intestines should not drink any sugary drinks. If they have colorectal cancer, take high-fructose corn. Syrup, equivalent to nourishing a patient's tumor. "

High-risk groups should avoid drinking any sugary drinks
One of the research authors, Cornell University Sandra and Edward. Lewis Cantley, director of the Meyer Cancer Center, said: "Research shows that large intestines are fed with high fructose corn syrup. Although the current research results are limited to mice, it can be inferred that sugar promotes cancer cell to grow and spread.

The experimental mice were adenomatous colonic sputum (APC) gene mutant mice, which were prone to inherited large intestines due to their innate inheritance and were often used to simulate early stage patients with colorectal cancer.

The experimental mice were fed continuously for 8 to 9 weeks with high fructose corn syrup mixed with glucose and fructose at 45:55, and forcedly fed 400 microliters of 25% syrup per day, accounting for approximately 3% of their daily calorie intake (equivalent to For adults, drink about 340 ml of soda per day, containing 20 grams of high fructose corn syrup. The research team used isotope labeling to track the effects of glucose and fructose in mice.
The study found that most of the corn syrup is not absorbed by the mice through the blood, and the large intestines can easily obtain growth energy from glucose and fructose. When compared with the mice fed only pure water, most of the corn syrup is fed. In the rat, although there is no more fat, it will make the large intestines grow bigger.
In addition, the research team also found that if the experimental mice had a mutation in the fructokinase (KHK) gene, feeding corn syrup would not cause significant differences in the growth of the large intestine. The analysis is that fructose kinase allows rapid metabolism of fructose molecules.