SEH® 997 Concentrated Solution

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SEH® 997 Concentrated Solution


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US FDA Registration Number: 16375280434 


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Below are the introduction and three animal experiments (Click to quickly browse):
Mice Colorectal ExperimentsWhite Blood Cell Tests, Pancreatic Cancer Experiments








SEH® 997 Concentrated Solution is an optimal nutritional supplement for cancer patients, which is made by a unique technology in the world. SEH® 997 can help adjust body composition, improve physical condition, nurture, and reinforce physical health. The manufacturing process, from material selection to production, features strict control. Certification by the third-party notary public SGS reassures compliance with safety and steady quality requirements.



 

(I.) Mice Colorectal Experiments:


SEH® 997 concentrated solution has passed various animal tests by Development Center for Biotechnology (DCB), Taiwan, which is a government grants organization and whose managing director is the President of Academia Sinica, Taiwan. In the animal tests, mice were injected with chemotherapy drugs, such as 5-Fluorouracil (5-FU) and Cisplatin. DCB lab confirmed the SEH® 997 Concentrated Solution can protect the liver function, and increase the White Blood Cell (WBC) numbers of mice by 1.8~3 times, Lymphocytes 1.2~4.7 times, Monocytes 1.8~11.3 times, and Granulocyte 2.1~3 times. Also, by using SEH® 997 with 5FU chemotherapy, tumors can be shrunk by 4-6 times compared with using 5FU chemotherapy alone. Meanwhile, DCB also confirmed when mice were injected with Taxol chemotherapy drug, SEH® 997 can minimize the side effect such as arrhythmias leading to cardiac hypertrophy, which may cause an increase in organ weights, such as heart, liver, spleen, and kidney, while relieving pain caused by Taxol.

Also, in the Cytokine experiments, DCB confirmed SEH® 997 concentrated solution has an effect of decreasing expression of human IL-8, IL-6, IL-1RA TNF-α Cytokine, and suppressing mouse G-CSF(p<0.05), IL-6, IL-12(p70) and human IL-12(p70) Cytokine expression.


                                       
                                                Comparison results of mice colorectal tumor volume




 

                                                           Comparison results of mice blood test










                                                        Comparison results of mice liver function test




                                                  Comparison results of mice visceral weight of injected Taxol





                                                             Taxol-induced cancer pain in mice

The oral administration of SEH® 997 concentrated solution was showed that the latency of tail-flick have been
trending increased compared with disease group whether on days 3, 7, and 14.



                                                          Comparison results of mice cytokine
 



 

(II.) White Blood Cell Tests:


SEH Biotechnology CO., LTD has consigned the Development Center for Biotechnology (DCB), Taiwan to accomplish the Cisplatin-induced leucopenia model (Experiment I) confirmed that after mice administered "Cisplatin" on day 0, in the first 3 days, administration of G-CSF white blood cell growth hormone for comparison with the SEH®997 concentrated solution with Top Spring® Life Energy Water (Eat SEH 997® for 7 days in advance), SEH®997 concentrated solution with Top Spring® life energy water (without eating SEH®997 for 7 days in advance) and SEH®997 concentrated solution with RO purified water (eat SEH 997® for 7 days in advance), on the seventh day we conduct complete blood cell (CBC) count and differential blood cell (DC) count, results are as the following:

The experimental results show that the mice which had SEH®997 Concentrated Solution and Top Spring® Life Energy Water for preceding seven days in the second group had the best White blood cells, Red blood cells, Platelet, Lymphocytes, Granulocyte cells enhancement after administering the chemotherapy drugs, followed by the third group which the mice did not have SEH®997 Concentrated Solution for preceding seven days. This evidenced that the SEH®997 Concentrated Solution has great protective effects on the mice.  Meanwhile, you can find the result in the second group that the mice had Top Spring® Life Energy Water are much better than the result in the fourth group which has the same condition with the 2nd group but the mice had different water, such as R.O. water. It is also proven that the Top Spring® Life Energy Water has the function to enhance the effectiveness of the nutritional supplements.








The Development Center for Biotechnology (DCB), Taiwan, accomplish the Cyclophosphamide-induced leucopenia model (Experiment II) confirmed that after mice administered the chemotherapy drugs "Cyclophosphamide", administration of G-CSF white blood cell growth hormone in the second to fourth days, and feed the mice with SEH®997 Concentrated Solution and Top Spring® Life Energy Water, and SEH® 997 Concentrated Solution with R.O. water to compare with each other, and the mice in each group were phlebotomized and also conduct complete blood cell (CBC) count and differential blood cell (DC) count on the 4th、7th、and 10th day, results are as the following:

The experimental results show that the mice which had SEH®997 Concentrated Solution and Top Spring® Life Energy Water in the fourth group had the best White blood cells, Lymphocytes, Monocyte, Granulocyte enhancement after administering the chemotherapy drugs, also the effect is better than administering  G-CSF. This evidenced that had the SEH®997 Concentrated Solution in advance has great protective effects on the mice. Meanwhile, you can find the result in the fourth group that the mice had Top Spring® Life Energy Water are much better than the result in the fifth group which has the same condition with the fourth group but the mice had different water, such as R.O. water.  It is also proven that the Top Spring® Life Energy Water has the function to enhance the effectiveness of the nutritional supplements.


       







(III.) Pancreatic Cancer Experiments:

The DCB conducted animal studies wherein mice were administered with human MIA-PaCa2 pancreatic cancer cells, followed by chemotherapy for two weeks and observation after two weeks. It was confirmed that the mice received current chemotherapy drugs such as "LV/5FU+ CPT11 (Liposome)" to simulate the leading Pancreatic and Colorectal cancer drug ONIVYDE®, which has been listed as the standard treatment for the pancreatic cancer patient group by the European Cancer Treatment Guidelines (ESMO Clinical Practice Guidelines, 2015) and the US Cancer Treatment Guidelines (NCCN Clinical Practice Guidelines, 2016). The result SEH®997 was combined with LV/5FU+CPT11(liposome) the tumor volume inhibition rate from 76% increase to 88% in 30 days. The Proinflammatory Cytokine IL-8 decreased from 77 pg/ml to 4 pg/ml (Blank 0 pg/ml and Disease 434 pg/ml). (Experiment I



Evaluation of efficacy of SEH®997 in a mouse Xenograft model for pancreatic cancer experiment I:








At present, the first-line treatment combination for pancreatic cancer in Taiwan is Leucovorin (LV)+Gemcitabine (GEM)+TS1, while in the United States; it is GEM +Abraxane (Abrax). However, the latest FDA-approved drug in the United States, "ONIVYDE®", which is recognized worldwide and uses the chemotherapy drug, CPT11 with liposome and adjuncts to 5FU + LV, has three months prolonged survival period, reaching an average of about 13 months as compared to patients who received GEM+Abrax, which is the first-line treatment combination for pancreatic cancer in the United States. This animal study used the combination of ONIVYDE® as chemotherapy for pancreatic cancer, LV/5FU+CPT11 (with liposome), and adjunct to SEH®997 Concentrated Solution. The study results confirmed that after adding SEH®997 Concentrated Solution, the tumor inhibition rate increased from 70.7% to 82.4%, with 50% more lymphocytes, an increase of 17% white blood cells and 27% more platelets, as compared to the group that received the combination of ONIVYDE®  chemotherapy alone. (Experiment II)


Evaluation of efficacy of SEH®997 in a mouse Xenograft model for pancreatic cancer experiment II:










In addition, there was liver cell damage that caused lethal hepatic necrosis when using the chemotherapy drug, 5FU in the ONIVYDE® combination as chemotherapy for pancreatic cancer, while a previous animal study of colon cancer conducted by the DCB wherein mice were administered with 5FU and SEH®997 Concentrated Solution, demonstrated liver protection function.

Something more worth mentioning, in our latest research in mouse models, we observed for the first time that the group treated with SEH®997 only had significantly lower pancreatic tumor development than disease group (p<0.01) and further indicated an increased tumor volume growth inhibition rate 34.2% in 31 days, which is compared with 32% by using PD-L1(10%) and 21% by using L1(1%)/CD3/CD28+IIron Oxide + Fucoidan. (Experiment III)



Evaluation of efficacy of SEH®997 in a mouse Xenograft model for pancreatic cancer experiment III:














The consumption dose of SEH®997 is 0.025 cc (5 drops) which must be diluted to 100-200cc of water. The total consumption dose per day is 0.15 cc (30 drops) to 0.25 cc (50 drops) which can be separated to 3 to 5 times per day, and the SEH997 better be skipped during the day of chemotherapy to get the best treatment result. (Experiment I Group 3 skipped the treatment day, Group 4 using SEH®997 every day)   

Besides, to accomplish the Cisplatin-induced leucopenia model confirmed by DBC that after mice administered “Cisplatin” and “Cyclophosphamide”, administration of G-CSF white blood cell growth hormone for comparison with the SEH®997 concentrated solution. The experimental results show that the mice which had SEH®997 had better white blood cells, lymphocytes enhancement after administering the chemotherapy drugs, also the effect is better than administering the drug G-CSF which may have many side effects.





SEH®997 concentrated solution has been approved by SGS after having met all requirements set for individual tests:

  • Heavy Metal Tests:As、Pb、Cd、Hg、Cu
  • Microbiological Tests:Aerobic Plate Count、Escherichia Coli、Salmonella、 Mold & Yeast Count、Staphylococcus Aureus
  • 398 Pesticide Residue Tests


 

  • Contains: 10ml
  • Shelf Life: 3 Years
  • Storage: Store in general room temperature
  • Recommended Usage: Drop 10 drops into 200-300ml drinking water (about one-thousandth-fold diluted), 30-50 drops every day.
  • 1cc = 20 drops, 10 drops per serving, each bottle contains 20 servings.

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